探讨促性腺激素释放激素拮抗剂对子宫内膜及胚胎的影响

来源 :广东省医学会第一次生殖医学学术会议暨广东省医学会生殖医学分会成立大会 | 被引量 : 0次 | 上传用户:liaotianeryi2
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  目的 探讨 体外受精-胚胎移植周期中应用促性腺激素释放激素(GnRH)拮抗剂(简称拮抗剂)超促排卵(COH)方案中对内膜的影响.方法 回顾性分析:分析我院在2010年4-10月份使用不同GnRH拮抗剂方案中临床结局HCG阳性与HCG阴性的临床一般情况.分为3组:1.达必佳(短效达必佳+拮抗剂+FSH/HMG)组93人,其中HCG阳性和HCG阴性的分别为32、61人;2.达英组(达英-35+拮抗剂+FSH/HMG)116人,其中HCG阳性和HCG阴性的分别为27、89人.;3.单拮抗剂方案组(拮抗剂+FSH/HMG) 46人,其中HCG阳性和HCG阴性的分别为27、89人.分别比较每组中HCG阳性和HCG阴性的年龄、窦卵泡数、使用促性腺激素(Gn)的量、Gn的时间、HCG日E2(雌激素)和LH水平、移植日内膜、可用胚胎形成率.同时选用2010第一季度使用GnRH激动剂长方案的可用胚胎形成率作为参照.结果 每组年龄除单拮抗剂组有差别外,余两组年龄无明显区别;每组窦卵泡数、使用Gn的量、HCG日E2、内膜均无明显区别.但是每组HCG阳性组有着使用Gn的时间长、获卵数多、E2水平较高的趋势,其中一组使用GN天数明显增长,P<0.05.三组(1、2、3)方案中可用胚胎形成率分别为(70.1%v61.0%,p=0.007<0.05)、(64.7%v58.2% p=0.054>0.05)、(66.9%V53.1% p=0.007<0.05),每组HCG阳性的可用胚胎形成率几乎均比HCG阴性的明显高,而长方案组为(60.1%v56.8%,P=0.168>0.05),差异不显著.结论 在体外受精-胚胎移植周期治疗中应用GnRH拮抗剂超促排卵方案中,胚胎的质量可能是导致妊娠结局失败的主要原因,说明在拮抗剂方案对内膜影响可能相对较小.
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目的 分析64名子宫畸形患者行IVF/ICSI治疗的临床资料,对子宫畸形患者的助孕结局做出分析总结,以期为临床提供借鉴.方法 回顾性分析2002年1月1日到2009年12月31日因不孕行IVF/ICSI治疗的子宫畸形患者,按照子宫畸形的类型进行分组,比较各组病人的基本资料及ART治疗结局.妊娠的患者追踪至分娩,比较自然流产率、早产率、活婴分娩率、新生儿体重和分娩孕周以及有无合并畸形.结果 因子宫畸