【摘 要】
：
Antibody-based therapeutics currently enjoy unprecedented success,growth in research and revenues,and recognition of their potential.It appears that the pro
【机 构】
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Protein Interaction Group Senior Investigator National Cancer Institute,NIH USA
【出 处】
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中国上海第七届国际新药发明科技年会
论文部分内容阅读
Antibody-based therapeutics currently enjoy unprecedented success,growth in research and revenues,and recognition of their potential.It appears that the promise of the "magic bullet" has largely been realized.There are currently 22 monoclonal antibodies (mAbs) approved by the United States Food and Drug Administration (FDA) for clinical use and hundreds are in clinical trials for treatment of various diseases including cancers,immune disorders and infections.The revenues from the top five therapeutic antibodies (Rituxan,Remicade,Herceptin,Humira and Avastin) nearly doubled from $6.4 billion in 2004 to $11.7 billion in 2006.These therapeutic and business successes reflect the major advances in antibody engineering which have resulted in the generation of safe,specific,high affinity,and non-immunogenic antibodies during the last three decades.
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