The aspartyl protease BACE1 as β-site the amyloid precursor protein (APP)-cleaving enzyme is involved in myelination.The previousstudies indicated BACE1 may be associated with AD and even as a candidate drug target for AD because of the increasing levelsof BACE1 protein and enzymatic activity within the brain homogenate of the frontal and temporal cortex in Alzheimers disease(AD)patients.