【摘 要】
：
Glucagon like peptide-1(GLP-1) was an important incretin released from the L-cells in the intestine upon food intake,it potently promotes insulin releasing from the 3-cells in the pancreas.1 GLP-1 was
【机 构】
：
Center of Drug Discovery,China Pharmaceutical University,24 Tongjiaxiang,Nanjing 210009
【出 处】
：
第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
Glucagon like peptide-1(GLP-1) was an important incretin released from the L-cells in the intestine upon food intake,it potently promotes insulin releasing from the 3-cells in the pancreas.1 GLP-1 was considered as an ideal anti-diabetic candidate for its crucial role in maintaining glucose homeostasis as well as hepatic and gastric function.However,the clinical application of native GLP-1 is restricted by its short circulating lifetime.After endogenous secretion of GLP-1,it is inactivated by dipeptidyl peptidase Ⅳ(DPP-Ⅳ) in minutes and rapidly cleared by kidneys.
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