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gamma-Butyrolactones in Streptomyces are well recognized as bacterial hormones and they affect secondary metabolisms of Streptomyces [1].In S.coelicolor,a well-known quorum-sensing system is composed of ScbA and ScbR:ScbA which has a high homology to fatty acid synthases can synthesize gamma-butyrolactone,and ScbR is the gamma-butyrolactone receptor [2].