The circulating microRNAs (miRNAs) own many characteristics of biomarkers and can be released from platelet.We hypothesize plasma miRNA level can reflect the effect of antiplatelet treatment in coronary heart disease.Our published data suggested that plasma miR-126 has the potential as a biomarker for predicting major adverse cardiac events in dual antiplatelettreated patients after percutaneous coronary intervention.In this paper, we aimed to systemically discover and evaluate plasma miRNAs specifically reflecting the response to clopidogrel sub-grouped by resistance or not to aspirin.① A total of 115 CAD patients received loading doses of clopidogrel 300 mg and aspirin 100 mg, platelet aggregation of asipirin response unit (ARU) and P2Y12 response unit (PRU) were detected respectively after 2 and 4 hours by verify now assay.The patients were divided into 16 groups according to the high or low ARU or PRU.The plasma from each subgroup (n=20) was pooled and then total RNA were extracted.