Objective: Central nervous system (CNS) progression is frequently detected in patients with favorable initial responses to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors (EGFR-TKIs), but
Objective: Lung cancer is the leading cause of cancer related death in the world.The last decade has witnessed the rapid development of epidermal growth factor receptor (EGFR) directed targeted therap
Objective: Although neoadjuvant chemotherapy (NAC) for advanced lung cancer can improve operability and local disease control, the duration of benefit is limited before resistance develops.
Objective: The central nervous system (CNS) is a frequent site of progression in ALK+ NSCLC patients treated with crizotinib, thus good CNS efficacy is of crucial importance for new ALK inhibitors.
Objective: IGNITE (a large, multinational, diagnostic, non-comparative, interventional study;NCT01788163) assessed EGFR mutation frequency in patients with advanced NSCLC of adenocarcinoma (ADC)/non-A
目的: Bulky local tumor (≥4cm)is a poor prognostic factor for early stage cervical cancer patients.Most of the locally advanced cervical cancer patients need postoperative radiotherapy.
Objective: To perform ameta-analysis on diagnosed brain metastases patients treated with whole-brain radiotherapy (WBRT) and stereotactic radiotherapy (SRT) boost versus WBRT alone, or inpatients trea
Objective: As one of the major cancers with a high mortality rate, lung cancer is still a huge health challenge worldwide.Although platinum-based doublet chemotherapy is the most common therapeutic re
Objective: Currently intensity-modulated radiotherapy (IMRT) is regarded as a promising but unproven therapy for locally advanced non-small cell lung cancer (LA-NSCLC).
Objective: c-Met abnormalities can cause resistance to EGFR TKIs in EGFR mutant NSCLC patients (pts).The highly selective c-Met inhibitor tepotinib (MSC2156119J) had promising activity in a phase Ⅰ tr