OBJECTIVE To explore the preparation technology of the puerarin self-microemulsifying system(Pue-SMEDDS).METHODS Puerarin solid self-microemulsion was prepared by spherical crystallization technique.Single factors exploration and the orthogonal design were used to optimize formulation and technology.Then the obtained Pue-SMEDDS was also evaluated.RESULTS The Pue-SMEDDS were sphere like with the particle sizes of 19.66nm and zeta potential of-28.2mV.About 10% of the drug was released from Pue-SMEDDS during 30min and above 80% of the drug was released during 24h.CONCLUSION The Pue-SMEDDS has high entrapment efficiency and drug loading, uniform particle size, good fluidity, which provides an extensive prospect for clinical application.The spherical crystallization technique can be used to prepare Pue-SMEDDS.