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Introduction: Regular moderate exercise training has many well-established health benefits;however,the benefits are lost with exhaustive exercise which even induces significant impairments.Evidences have shown that Lycium barbarum polysaccharides (LBP) can enhance exercise endurance capacity, reduce fatigue and exhibit antioxidant activity.The aim of this study was to investigate the effects of LBP on arterial compliance in rats after exhausted swimming exercise.Method: The animals were divided into four groups, including control, aerobic,exhausted and exhausted+LBP groups.Exercised groups were submitted to a four weeks swimming training protocol.Body weight and endurance time of each rat were recorded.The concentration of malondialdehyde (MDA),super oxide dismutase (SOD), lactic acid (LD) and nitric oxide (NO) were determined in plasma by using flowthrough spectrophotometry;Heat shock protein 70 (HSP70) in plasma was made by ELISA.A tension of aorta rings was measured to evaluate the response on noradrenaline (NA)-induced contraction.Results: After exhaustive exercise, the mean endurance time of swimming to exhaustion of rats in LBP treated groups were significantly prolonged compared with that in the exhausted group.Contractile response to NA in exhausted+LBP group was significantly depressed.LBP could reduce the accumulation of lactic acid and MDA level and increase SOD,NO and HSP70 levels in serum(P<0.05).Conclusion: LBP could reduce contractile responses to NA in isolated thoracic aortas tested and improve arterial elasticity.