【摘 要】
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Homeostatic regulation of synaptic properties in response to chronic alteration of neuronal activity is essential for neural circuit function,but the underlying mechanism is largely unknown.Here we fo
【机 构】
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Institute of Neuroscience and Key Laboratory of Neurobiology, Institutes for Biological Sciences, Ch
【出 处】
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中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
论文部分内容阅读
Homeostatic regulation of synaptic properties in response to chronic alteration of neuronal activity is essential for neural circuit function,but the underlying mechanism is largely unknown.Here we found that changes of neuronal activity led to corresponding alterations in the expression of brain-derived neurotrophic factor (BDNF) and TrkB phosphorylation,as well as in the level of synaptic proteins.Exogenous BDNF reversed changes in synaptic proteins induced by chronic activity blockade,while Trk inhibition or depleting endogenous BDNF blocked the changes of these proteins induced by chronic activity elevation.Different downstream pathways of BDNF signaling were found to be responsible for modulating different sets of proteins.Furthermore,exogenous BDNF was sufficient to increase ubiquitination of synaptic proteins,whereas inhibition of endogenous BDNF-TrkB prevented ubiquitination of synaptic proteins induced by chronic elevation of neuronal activity.Thus BDNF-TrkB signaling acts upstream from ubiquitin proteasome system (UPS),mediating homeostatic regulation of synaptic properties.
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