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Statins are widely used hypocholesterolemicdrugs by blocking the mevalonate pathway.Some reports have shown that statin may have the potential to inhibit degeneration of intervertebral disc.IL-1β,as a catabolic cytokines,is a key regulator of IVD degeneration.This study was undertaken to investigate the mechanism of simvastatin in the intervertebral disc(IVD)degeneration.