【摘 要】
:
Discovery and development of therapeutic protein dugs have been a major focus in the pharmaceutical industry in recent years.Understanding pharmacokinetic/p
【机 构】
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Waters Technologies (shanghai) Limited Company, Shanghai 201206, China
【出 处】
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2015年第一届药代动力学朝阳论坛
论文部分内容阅读
Discovery and development of therapeutic protein dugs have been a major focus in the pharmaceutical industry in recent years.Understanding pharmacokinetic/pharmacodynamic relationships of these drugs is critical in preclinical and clinical studies.Historically, immunological techniques such as enzyme-linked immunosorbent assay (ELISA) have been used to quantify protein drug.However, these assays have major drawbacks, such as lengthy development time, difficulties in getting suitable antigen;Nowadays, liquid chromatography coupled with mass spectrometry (LC-MS/MS) has been increasingly used for quantification of therapeutic proteins.
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