【摘 要】
：
Objective Dickkopf-1(DKK1) is antagonist to Wnt signaling pathway.Our aim was to investigate the association between DKK1 gene polymorphisms and bone response to alendronate treatment in Chinese postm
【机 构】
：
Department of Endocrinology, Key Laboratory of Endocrinology of Ministry of Health, Peking Union Med
【出 处】
：
中华医学会第七次全国骨质疏松和骨矿盐疾病学术会议
论文部分内容阅读
Objective Dickkopf-1(DKK1) is antagonist to Wnt signaling pathway.Our aim was to investigate the association between DKK1 gene polymorphisms and bone response to alendronate treatment in Chinese postmenopausal women with osteoporosis or osteopenia.
其他文献
Background and aims Age at menarche and menopause are associated with cardiovascular disease, diabetes and osteoporosis in Caucasian women,but associations remain unexplored in Chinese women.Therefore
目的 本研究通过测定绝经前后女性的骨密度(BMD)、颈动脉及股动脉的动脉粥样硬化相关指标及血清骨保护素(OPG)和骨桥蛋白(OPN)等骨特异性标志物,旨在了解绝经后骨质疏松症(PMOP)患者骨密度与动脉粥样硬化(AS)之间的关系,初步探讨OPG、OPN在AS与PMOP发生、发展过程中的作用,为进一步全面认识AS与PMOP之间的相关性及发病机制提供理论依据,为临床预防和治疗这两种疾病提供新的研究思路
目的 探讨中药杜仲补骨脂药对调节去卵巢大鼠骨组织基质金属蛋白酶3-骨桥蛋白受体传导通路中蛋白表达水平.方法 6月龄雌性SD大鼠105只,随机分为模型组75只、假手术组30只.术后12周,每组各随机抽取实验大鼠15只,处死取材.
目的 近年来,"衰老与氧化应激(oxidative stress,OS)"作为骨质疏松症的发病机制越来越受到重视,而抗氧化剂可能防治骨质疏松.本课题组研究发现,丹参素(Tanshinol)是丹参水溶性成的抗氧化成分,具有明显的抗骨质疏松作用.基于此,本研究采用具有多分化潜能的间充质细胞C2C12,研究OS对其增殖及成骨分化的影响,并探讨Tanshinol的干预作用及其机制.
目的 维生素D缺乏是一个全世界范围内的公共卫生问题.维生素D维护骨骼和肌肉系统正常功能的重要物质,维生素D缺乏可能导致继发性甲状旁腺亢进,从而导致骨转换率升高和骨量丢失.我们之前的研究发现维生素D代谢通路基因多态性与血清25(OH)D水平有显著相关性,但是这些位点是否能够预测骨转换生化指标水平仍有待研究.
Backgrounds and Objective Bone morphogenetic protein (BMPRIA)-mediated signaling pathway has been shown play an important role in controlling bone hemostasis in mice.In the present study, we aimed to
Objective Fibrodysplasia ossificans progressiva, an ultra-rare and disabling genetic disorder of skeletal malformations and progressive heterotopic ossification (HO), is the most catastrophic conditio
Introduction It was reported that iron overload is a risk factor of osteoporosis.However, in these studies, animals vary from mice to rat and pig, and were experimentally iron overloaded.The results o
Objective Fracture healing is a complex process that involves both anabolic and catabolic responses.At the onset of fracture repair there is an initial inflammatory phase followed by the differentiati
Background Recombinant human parathyroid hormone (1-34) (rhPTH (1-34)) given by injection is a new seventh class drug of biological products, which is prepared by adopting gene recombination technique