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Urea transporter B (UT-B) is a membrane protein extensively expressed in various tissues, such as kidney, testis, brain, bone marrow, spleen and erythrocyte, but the specific biological function is well clarified in kidney.UT-B expressed in kidney descending vasa recta (DVR) endothelial cells mediates the passive transport of urea down its concentration gradient, indispensably in urea recycling and urine concentration.