【摘 要】
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Objectives The receptors of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) comprises death receptors (DR4, DR5),decoy receptor (DcR) and osteoprotegerin (OPG).In theory, the balance a
【机 构】
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Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzho
【出 处】
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The 14th Congress of Gastroenterology China(第十四届全国消化系病学术会议)
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Objectives The receptors of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) comprises death receptors (DR4, DR5),decoy receptor (DcR) and osteoprotegerin (OPG).In theory, the balance and interaction between each of the TRAIL receptors were suggested to play a crucial role in the sensitivity of target cells to TRAIL-induced apoptosis.Our preliminary study showed that the polymorphisms of 3 untranslated region in TRAIL gene were correlated with the susceptibility to ulcerative colitis (UC).Therefore, the present study aimed to further analyze the associations between the common mutations of TRAIL receptors and UC.
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