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Regulatory T (Treg) cells are now generally recognized to play a pivotal role in immune functions and diseases.However,no antibodies are available for studies in tree shrews.We have first cloned the full-length coding genes for the surface markers and functional molecules of tree shrew Tregs [CD3 (ε chain),CD4,CD25,CD127,CTLA-4 and PD-1] and then successfully generated a full panel of monoclonal antibodies against them.