【摘 要】
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Malignant tumor is a common and multiple disease severely threatening humans lives.Searching for new antitumor drugs with high effects and selectivity becomes a tough problem to modern researchers.Rec
【机 构】
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Department of Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009
【出 处】
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第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
Malignant tumor is a common and multiple disease severely threatening humans lives.Searching for new antitumor drugs with high effects and selectivity becomes a tough problem to modern researchers.Recently researchers indicated that VEGF receptor tyrosine kinase inhibitors could block VEGF/VEGFR signaling pathways,accordingly,prevent metathesis,growth and survival of new endothelial cells around tumors.Moreover,pyrimidine derivatives as the key nucleus were reported to show inhibition against tyrosine kinase.In this work,a series of oxazolo[5,4-d]pyrimidine derivatives were successfully designed,synthesized and evaluated for the VEGF/VEGFR signaling pathway inhibitory activities.
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