Biomarker Research: From Basic Science to Clinical Diagnostics and Therapeutics

来源 :2014第七届世界癌症大会 | 被引量 : 0次 | 上传用户:leolover211
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Personalized arid molecular-based cancer treatment depends on biomarkers.Biomarker research and assay development could drive drug discovery, clinical diagnostics, prognostics and treatment decisions.Immunohistochemistry (IHC), which examines protein biomarker expression in combination with tissue morphology, has become more and more important in assays that required using archival formalin-fixed, paraffin embedded (FFPE) tissues.
其他文献
How to define sensitivity and validation in next generation diagnoses?-How to concurrently achieving highest sensitivity and lowest false positivity.Can it possible using traditional PCR to enrich mul
会议
Although mechanisms of the action have yet been well-understood, non-steroidal anti-inflammatory drugs (NSAIDs) are widely reported to display strong efficacy for cancer prevention.The most known anti
会议
Monoclonal antibody (McAb) is the key tool for cancer immunodiagnosis and immunotherapy.In this study, a cell clone which kept secreting high-titer IgGl-type McAb named N J001 against human non-small
会议
Many specific molecular alterations in soft tissue and blastemal tumors have been described recently.These modifications are usually specific and their detection allows an accurate tumor classificatio
会议
Determining the in-situ immune status of diseased organs is mostly subject to visual estimation, or-at best-to manual counting.Hence, experts usually have the choice of the "least of evils" between gu
会议
EML4-ALK fusion gene is found in only a small subset (2-6%) of non-small cell lung cancer.Using high sensitive and specific detection method to identify this rare but important fusion in patients with
会议
There is increasing evidence that circulating tumour cell (CTC) presence in patient blood is an important indicator of poor prognosis.Thus, quantification of CTCs may advance prognosis.To quantify and
会议
Non-invasive, accurate tests to screen for early stages ofcolorectal cancer (CRC) are not available today.The aim of this study is to further develop and validate a test that differentiates subjects w
会议
Current investigation for patients with colorectal symptoms without overt rectal bleeding is undertaken by colonoscopy or by flexible sigrnoidoscopy and barium enema.A large majority of patients do no
会议
The diagnostic test of ALK rearrangement in non-small-cell lung cancer (NSCLC) for crizotinib treatment is currently done on tumor biopsies or fine needle aspirations.The present study was designed to
会议