Objectives To determine which methods and criterias are most frequently used diagnosing SCAA,and to explore the distribution of diagnosis types in different time period and regions in order to support future.Methods Relevant studies were identified by searching the electronic bibliographic databases),scanning references listed in articles and handsearching journals.Studies were eligible for inclusion if they had diagnosed CAA on pathological examination of a brain biopsy or autopsy or clinical diagnostic criteria in patients with spontaneous ICH.Two authors screened all titles and abstracts for eligibility,removed duplicates and read the full text of articles that were potentially eligible for inclusion.Eligible studies were read in full by two authors who extracted data independently on the following:study design,patient type,time range nationality,geographic distribution,mean age at diagnosis (SD if available),age range at diagnosis,sex,complaint,major symptoms,risk factors,ICH diagnosis type & number,ICH locations & number,methods of assessment and grading of CAA,and whether anv confounders were accounted for.Results 1491 studys were identified for 317 included (3622 patients).detailed results are in a form complex,and will be presented on the conference.Conclusions Most CAA diagnosis are made upon pathological sampling as autopsy and biopsy,while a well design comprehensive clinical diagnostic criteria -the Boston criteria also being used in part of the world especially in America and Europe.Beside,in recent decade muitiple nova techniques,radiological,biochemical and genetic alike,are emerging in CAA detection.It is necessary to further promote the clinical diagnosis criteria and new techniques so that etiological classification could be made for better personalised CAA-related SICH management.