【摘 要】
:
A novel series of 1,3-diphenyl-2-propen-1-one(chalcone)derivatives was synthesized by a simple,ecofriendly,and efficient Claisen-Schmidt condensation reaction and used as precursors for the synthesis
【机 构】
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Drug and Herbal Research Centre,Faculty of Pharmacy,Universiti Kebangsaan Malaysia,Jalan Raja Muda A
【出 处】
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第八届国际分子模拟与信息技术应用学术会议
论文部分内容阅读
A novel series of 1,3-diphenyl-2-propen-1-one(chalcone)derivatives was synthesized by a simple,ecofriendly,and efficient Claisen-Schmidt condensation reaction and used as precursors for the synthesis of new pyrazoline derivatives.All the synthesized compounds were screened for anti-inflammatory related activities such as inhibition of phospholipase A2(PLA2),cyclooxygenases(COX-1 and COX-2),IL-6,and TNF-α.The results of the above studies show that the compounds synthesized are effective inhibitors of above pro-inflammatory enzymes and cytokines.Over-alt,the results of the studies reveal that the pyrazolines with chlorophenyl substitution(1b-6b)seem to be important for inhibition of enzymes and cytokines.Molecular docking experiments were performed to clarify the molecular aspects of the observed COX-inhibitory activities of the investigated compounds.
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