A novel series of 1,3-diphenyl-2-propen-1-one(chalcone)derivatives was synthesized by a simple,ecofriendly,and efficient Claisen-Schmidt condensation reaction and used as precursors for the synthesis of new pyrazoline derivatives.All the synthesized compounds were screened for anti-inflammatory related activities such as inhibition of phospholipase A2(PLA2),cyclooxygenases(COX-1 and COX-2),IL-6,and TNF-α.The results of the above studies show that the compounds synthesized are effective inhibitors of above pro-inflammatory enzymes and cytokines.Over-alt,the results of the studies reveal that the pyrazolines with chlorophenyl substitution(1b-6b)seem to be important for inhibition of enzymes and cytokines.Molecular docking experiments were performed to clarify the molecular aspects of the observed COX-inhibitory activities of the investigated compounds.