【摘 要】
：
致病性大肠杆菌是医学和兽医学临床感染中最常见的病原菌之一,其中肠出血性大肠杆菌O157∶H7是典型代表菌株,常引起人和动物的感染与流行.自20世纪80年代发现该菌株以后,在日本等多个国家和地区都有不同规模的流行和爆发.据统计,全球每年因感染产毒大肠杆菌至少可导致6.5亿人发病,并引起约80万名5岁以下儿童死亡.O157感染通常能够引起出血性肠炎、溶血性尿毒综合征和血小板减小性紫癜等疾病.由于其致病
【机 构】
：
吉林大学动物医学学院,长春,130062;中国水产科学研究院长江水产研究所 吉林大学动物医学学院,
【出 处】
：
中国畜牧兽医学会兽医药理毒理学分会第十一届会员代表大会暨第十三次学术讨论会与中国毒理学会兽医毒理专业委员会第五次学术研讨
论文部分内容阅读
致病性大肠杆菌是医学和兽医学临床感染中最常见的病原菌之一,其中肠出血性大肠杆菌O157∶H7是典型代表菌株,常引起人和动物的感染与流行.自20世纪80年代发现该菌株以后,在日本等多个国家和地区都有不同规模的流行和爆发.据统计,全球每年因感染产毒大肠杆菌至少可导致6.5亿人发病,并引起约80万名5岁以下儿童死亡.O157感染通常能够引起出血性肠炎、溶血性尿毒综合征和血小板减小性紫癜等疾病.由于其致病力强、感染剂量低、潜伏期长,使得对O157感染成为全球性的公共卫生问题,严重威胁人类的健康.尽管抗生素是治疗细菌性感染的主要途径,但使用抗生素治疗肠出血性大肠杆菌感染会加重罹患溶血性尿毒综合征的风险.因此,研发具有全新机制的抗耐药性大肠杆菌O157感染的药物十分迫切.志贺样毒素是肠出血性大肠杆菌O157∶H7致病过程中最关键的毒力因子.志贺样毒素分为Ⅰ型志贺毒素和Ⅱ型志贺毒素两种.其中,Ⅱ型志贺毒素(Stx2)毒性较强,是出血性肠炎和溶血性尿毒综合征发生的基础.
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