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Purpose Previous study indicated that HLA-B*1502 is strongly associated with carbamazepine(CBZ) inducedStevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in HanChinese, whileHIA-A*3101 is associated with CBZ induced cutaneous adverse reactions in Japanese and European.However, the relationship between HLA allele and CBZ induced maculopapular exanthema reactions(CBZ-MPE) was unclear.We thus investigated the involvement of HLA-A, B, C, DRB1 allelesinCBZ-MPE in southern HanChinese patients.Method We carried out a case-control association study.We enrolled 60CBZ-MPE, 137 CBZtolerant subjects and 5270 healthy volunteers as normal controls.The ethnicity of all cases and controls was HanChinese., comingfrom locations in southern China.Sequencing for four-digit genotyping was performed.A 2-by-2 X 2 test or Fisher' s exact test was used.Results HLA-B*1502 was present in 11 of 58 (18.9%) CBZ-MPE, HLA-A*3101 was present in 5 of 60 (8.3%) CBZ-MPE, the frequency of HLA-B*1502, HLA-A*3101 in CBZ-MPE did not differ significantly from that in CBZ-tolerant controls and normal controls.Conclusion No significant association between HLAalleleandCBZ-MPE was found.The associations between CBZ-MPE and HLA alleles warrant further studies.