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We show a upper bound heat kernel estimate for operator $Delta +
abla(-frac{1}{|x|^alpha})cdot
abla$($alpha>0$)on $R^nsetminus{0}$.To this aim,we also show an isoperimetric inequality for weighted measure $e^{-frac{1}{|x|^alpha}}dx$ via functional form isoperimetric inequality.This is a joint work with Alexander Grigoryan and Michael Roeckner.