【摘 要】
：
HIV-1 depends on host-cell-encoded factors to complete its life cycle.A comprehensive understanding of how viruses manipulate host machineries during the course of HIV-1 infection can facilitate the i
【机 构】
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Key Laboratory of Molecular Virology and Immunology,Institute Pasteur of Shanghai,Chinese Academy of
【出 处】
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第十一届全国病毒学学术研讨会暨第六届武汉现代病毒学国际研讨会
论文部分内容阅读
HIV-1 depends on host-cell-encoded factors to complete its life cycle.A comprehensive understanding of how viruses manipulate host machineries during the course of HIV-1 infection can facilitate the identification of host targets for antiviral drugs or gene therapy.The cellular protein Nafl(HIV-1 Nef-associated factor 1)is a CRM1(also known as Exportinl)-dependent nucleo-cytoplasmic shuttling protein,and has previously been identified to regulate multiple receptor-mediated signal pathways in inflammation.
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