【摘 要】
：
Objectives Adriamycin (ADR) has broad-spectrum effect such as anti-tumour and antibiotic, but it is limited the application for its dose-dependent cardiac toxicity.PICK1 is the interaction protein of
【机 构】
：
Department of Pharmacology,Hubei University of Science and Technology,Xianning 437100,China;Hubei Pr
【出 处】
：
第二十四届长城国际心脏病学会议、亚太心脏大会暨国际心血管病预防与康复会议(The 24th Great Wall Int
论文部分内容阅读
Objectives Adriamycin (ADR) has broad-spectrum effect such as anti-tumour and antibiotic, but it is limited the application for its dose-dependent cardiac toxicity.PICK1 is the interaction protein of PKC, which has been suggested as a potential drug target against brain ischaemia, pain and cocaine addiction.Our previous study has shown that the expression of PICK1 has increased in ADR-induced toxic myocarditis.
其他文献
目的:探讨大剂量阿托伐他汀钙序贯治疗对择期行经皮冠状动脉介入治疗(PCI)患者对比剂肾病(CIN)的防治作用.方法:将2010年9月～2012年4月在我院确诊为急性非ST段抬高型心肌梗死并行择期PCI患者100例随机分为大剂量他汀序贯治疗组(A组)和阳性对照组(B组).所有患者入院即刻给予给予80mg阿托伐他汀钙,随后40mg/d.所有患者术前均给予水化治疗.A组:术前6小时内追加40mg阿托伐他
目的:采用24h动态血压监测研究阿雷地平肠溶胶囊对轻、中度原发性高血压患者的血压变异性(BPV)和动态动脉僵硬度指数(从SI)的影响.方法:开放试验.7 4例95≤舒张压(DBP) ＜110mmHg(1mmHg=0.133kPa)和/或140≤收缩压(SBP) ＜180mmHg的轻、中度高血压患者在2周安慰剂清洗期后给予5mg/d阿雷地平肠溶胶囊,4周后如诊室谷值坐位SBP/DBP＜ 140/90
Objectives To explore the effects of Qishen Granule, a compound Chinese herbal medicine, on hemodynamics in a mini pig model of cardiac functional insufficiency and qi-deficiency and blood stasis synd
Objectives The benefit of blocking the renin-angiotensin system (RAS) with conventional RAS blockers in cardiovascular diseases and nephropathy of patients with type 2 diabetes is now well established
Objectives Rats were exposed to infrasound for several weeks,and adverse effects on the cardiovascular system were demonstrated using morphology, histopathology, and histochemistry.The aim of the pres
Objectives To investigate the possible role of PI3k/Akt/GSK-3 signalling pathway in the pathogenesis of endothelial cells injury and oxidative stress induced by high glucose fluctuation in type 2 diab
Objectives To explore the feasibility, safety, and anti-apoptosis effect and to investigate the therapeutic potential of gene modified by adeno-associated virus combined with PDGF-BB in MI.Methods The
Objectives Sonodynamic therapy (SDT) was developed as a localised ultrasound-activated cytotoxic therapy for cancers.The ability of SDT to destroy target tissues selectively is especially appealing fo
Objectives Salt-sensitive hypertension is a leading risk factor contributing to the development of chronic renal disease.We found that high-salt intake activated sensory nerves, leading to release of
Objectives Scavenger receptor BI (SR-BI) is a key regulator of high density lipoprotein (HDL) metabolism.Recent studies showed that mice deficient in SR-BI exhibit impaired erythropoiesis and it has b