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The use of vaccination for controlling PRRS at a regional level would be greatly facilitated if vaccination reduced significantly the probability of infection or transmission of PRRSV among vaccinated pigs.With the objective of quantifying transmission of PRRSV under quasi-natural conditions and estimating how the basic reproduction ratio (R0) can be modified by piglet vaccination,a trial of heterologous challenge was conducted.Initially,98 three-week-old PRRSV-na(i)ve piglets were divided in two groups:vaccinated animals (V,n=40) that received an intramuscular dose of a commercial modified live vaccine (MLV) and unvaccinated animals (NV,n=58) which did not receive any treatment.