The adult intestinal homeostasis is tightly controlled by proper proliferation and differentiation of intestinal stem cells.The JAK/STAT (Janus Kinase/Signal Tr
Highlights:1) Maternal Ascl1 functions as a repressor during mesendoderm pattern formation.2) Ascl1 recruits HDAC 1 to repress the transcriptional activity
In artificial insemination, semen quality is considered to be closely related to the pregnancy rate and ratio of embryo development into fetus.The aim of th
The cellular origin of gastric cancer remains elusive.Lgr5 is the first identified gastric stem cell marker.However, the role of Lgr5+ stem cells in driving
Patterning of nervous system requires precise input of the spatial cue.In our study, we found that the deneddylation complex CSN determine neural competence at
SUMO (Small ubiquitin-related modifier) modification (SUMOylation) is a highly dynamic post-translational modification playing important roles in tissue dev
Successful incorporation of the paternal genome into the zygote represents one of the most fundamental requirements for maintaining genome integrity.During
The derivation of female germ cells provides the capability to study human oogenesis.Previously, we reported that female germ cells were triggered from CD11
Angiosperms are the most successful plants and support human livelihood and ecosystems.Angiosperm phylogeny is the foundation of studies of gene functionand