Spinal IL-33/ST2 Signaling Contributes to Neuropathic Pain via Neuronal CaMKⅡ-CREB and Astroglial JA

来源 :The 6th Asian Pain Symposium, APS 2015(第六届亚洲疼痛研讨会) | 被引量 : 0次 | 上传用户:yidehua_2
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Emerging evidence indicates that nerve damage-initiated neuroinflammation and immune response, which are evidenced by the up-regulation of proinflammatory cytokines, contribute to the development of neuropathic pain.
其他文献
Objective: Peripheral sensitization has been demonstrated to play a key role in the induction and persistence of neuropathic pain.Previous studies had contradictory reports about the role of CaV3.2 T-
Neurons express more genetic information encoded in DNA than cells from other organs, resulting in the heterogeneity of neuron types.Sensory neurons are specialized by receptive characters.Therefore,
Chronic pain is a serious health challenge in aged society.Patients life quality decreased and the cost of medical care increased massively.About 7~15% patients with hemorrhage stroke in lateral thala
Deep brain stimulation (DBS) at sensory thalamus and periventricular gray (PVG)/ periacqueductal gray (PAG) has been used for neuropathic pain treatment.Multiple neural oscillations in sensory thalamu
Symptoms including anhedonia, decreased motivation and depression are common affective features in patients with chronic pain.Recent evidence implicated that pathological adaption in the nucleus accum
Objective: Nuclear factor-kappa B (NF-κB) signaling is implicated in both cancer development and inflammation processes, and has been suggested as a possible target in pain treatment.
Autophagy is a process of cellular self-cannibalization, and provides an adaptive mechanism to protect cells against diverse pathological settings.Following peripheral nerve injury, autophagic process
Background: Emerging evidence indicates that nerve damage-initiated neuroinflammation and immune responses, which are evidenced by the up-regulation of proinflammatory cytokines, contribute to the dev
会议
Background: Hydrogen sulfide (H2S), an endogenous gaseotransmitter/modulator, is becoming appreciated that it may be involved in a wide variety of processes including inflammation and chronic.
Human T lymphocytes, bearing T-cell receptor (TCR) γδ, play an important role in tumor immunosurveillance and antitumor immune responses.Functionally, without negative selection during thymus developm
会议