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Purpose Several clinical studies and experimental evidence have demonstrated that increased macrophage infiltration into tumors confers metastatic potential and poor prognosis in cancer.Development of lung metastasis worsens the prognosis,and complete remission of the metastasis is infrequently achieved in clinics; therefore,preclinical studies are needed to develop new strategies for countering metastasis.The present study was designed to investigate the impact of pulmonary macrophages on lung metastasis of anaplastic thyroid cancer(ATC).