【摘 要】
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In this work,we developed a new technology by the combination of microfluidic device with mass spectrometry for the study of cell drug metabolism and cell-cell information exchange.The microfluidic de
【机 构】
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Department of Chemistry,Beijing Key Laboratory of Microanalytical Methods and Instrumentation,Tsingh
【出 处】
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第九届全国微全分析系统学术会议、第四届全国微纳尺度生物分离分析学术会议、2014国际微流控芯片与微纳尺度生物分离分析学术
论文部分内容阅读
In this work,we developed a new technology by the combination of microfluidic device with mass spectrometry for the study of cell drug metabolism and cell-cell information exchange.The microfluidic device contains two different functional units:(1) a circular cell culture chamber;(2) a micro-solid phase extraction channel for sample cleanup and concentration prior to mass analysis.By connecting the two separated microchannels with polyethylene tubes,drug metabolism studies related to functional units,containing cell culture,metabolism generation,sample pretreatment and detection were all integrated into a microfluidic device.
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