Anticancer drugs embedded in or conjugated with nanocarriers have shown obvious therapeutic advantages over carrier-free drugs,yet they still face the problems like low drug loading capacity,possible
Two antiprine derivatives,4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)antipyrine (DOPAP) and 4-(1,3-dioxoisoindolin-2- yl)antipyrine (DOIAP),were responsively synthesized by the condensation reaction of 4-aminoan