Heparan sulfate (HS) play an important role in neural development.The glucuronyl C5-epimerase (Glce) is one of the critical modification enzymes involved in biosynthesis of HS.Targeted interruption of the gene Glce resulted in neonatal lethality in mice.Despite its vital importance in early development stage, however, very little is known about the functions and underlying mechanisms of Glce in central nervous system.