【摘 要】
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Angiogenesis is a highly regulated event involving complex, dynamic interactions between microvascular endothelial cells and extracellular matrix (ECM) proteins.Alteration of ECM composition and archi
【机 构】
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California Northstate University College of Pharmacy USA
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Angiogenesis is a highly regulated event involving complex, dynamic interactions between microvascular endothelial cells and extracellular matrix (ECM) proteins.Alteration of ECM composition and architecture is a hallmark feature of wound clot and tumor stroma.We previously reported that during angiogenesis, endothelial cell responses to growth factors are modulated by the compositional and mechanical properties of a surrounding three-dimensional (3D) extracellular matrix (ECM) that is dominated by either cross-linked fibrin or type Ⅰ collagen.This study demonstrates that fibrin and type Ⅰ collagen 3D matrices differentially but synergistically regulate sprout angiogenesis.
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