The present study was designed to reveal the potential role of let-7c-5p,a highly conserved miRNA in stroke.We found that the content of let-7c-5p was significantly decreased in the plasma of patients
Columnar restriction is commonly observed in vertebrates and invertebrate nerve system,which helps to form non-overlapping receptive fields and preserve the spatial sensory information from the periph
Zinc finger E-box binding homeobox 1(Zeb1)is a key regulator of epithelial-mesenchymal transition(EMT),which is critical for invasion and metastasis of carcinoma cells,as well as embryonic development
The transcription factor nuclear factor erythroid-2-related factor 2(Nrf2)and its target heme oxygenase-1(HO-1)play critical role in the anti-oxidative defense against different kinds of toxic insults
Dendrite development of newborn granule cells(GCs)in the dentate gyrus of adult hippocampus is critical for their incorporation into existing hippocampal circuits,but the cellular mechanisms regulatin
Objective Loss-of-function mutations in the gene encoding glucocerebrosidase(GBA),the enzyme deficient in the lysosomal storage disorder Gaucher disease,elevate the risk of Parkinsons disease(PD),whic
Amyloid-beta(Aβ)plays a pivotal role in the pathogenesis of Alzheimers disease(AD).The physiological capacity of peripheral tissues and organs in clearing Aβ in the brain and its therapeutic potential