【摘 要】
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Purpose: Although accumulative evidences indicated that circulating endothelial progenitor cell(CEPC)contributes to tumor neovascularization,to our knowledge,the level of CEPCs and its correlation wit
【机 构】
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上海市第十人民医院 同济大学附属第十人民医院泌尿外科
【出 处】
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2012上海市医学会泌尿外科、男科学术年会
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Purpose: Although accumulative evidences indicated that circulating endothelial progenitor cell(CEPC)contributes to tumor neovascularization,to our knowledge,the level of CEPCs and its correlation with serum vascular endothelial growth factor(VEGF)in patients with renal cell carcinoma(RCC)havent been studied.We measured the level of CEPCs and investigated its clinical significance in RCC patients.Materials and Methods: The level of CEPCs(percentage of total peripheral blood mononuclear cells)was quantified by assaying the CD45-CD34+VEGF-Receptor 2+cell phenotype in 53 RCC patients,33 benign renal tumor(BRT)patients,and 40 healthy controls(HCs).Meanwhile,serum VEGF concentration was quantified.Results: Mean CEPC level in RCC patients was 0.281％,which was significantly higher than BRT patients(0.073％,p＜0.001)and HCs(0.076％,p＜0.001).Patients with stage Ⅲ-Ⅳ RCC had a statistically higher CEPC level than stage Ⅰ-Ⅱ(0.339％ vs.0.243％,p＜0.001).Mean CEPC level in patients with ＞7cm RCC was 0.331％,which was significantly higher than those with tumors≤4cm(0.225％,p＜0.001)and 4-7cm(0.231％,p＜0.001).Mean serum VEGF concentration in RCC patients(315.5pg/ml)was higher than BRT patients(34.6pg/ml,p＜0.001)and HCs(26.9pg/ml,p＜0.001).Preoperative CEPC level positively correlated with serum VEGF in RCC patients(r=0.710,p＜0.001).The CEPC and VEGF levels demonstrated significant decreases after surgery(CEPC: 0.081％ vs.preoperative 0.297％,p＜0.001; VEGF: 31.69pg/ml vs.preoperative 310.70pg/ml,p＜0.001).Conclusion: High level of CEPCs was found in RCC patients and it positively correlated with serum VEGF concentration.Our results support the potential use of CEPC as a novel biomarker for RCC patients.
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