Thiol "click" chemistry is an attractive tool for postpolymerization modification of thiolmers or thiol containing substrates in the field of biomedical applications,while thiol groups are easily oxidized,limiting the potential for covalent immobilization of bioactive molecules.In this study,a series of biodegradable polyurethane elastomers incorporating stable cyclic disulfide groups was developed and characterized,via the subsequent click reaction to provide a novel facile and efficient strategy of biofunctionalization.