【摘 要】
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Objective Checkpoint kinase 2(Chk2),a major cell cycle regulatory kinase,provides a barrier to tumorigenesis due to the DNA damage response,which preserves the genomic stability of cells.In previous r
【机 构】
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China Pharmaceutical University
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Objective Checkpoint kinase 2(Chk2),a major cell cycle regulatory kinase,provides a barrier to tumorigenesis due to the DNA damage response,which preserves the genomic stability of cells.In previous reports,Chk2 inhibition exhibits potential antitumor effects in combination with radiotherapy and chemotherapeutics in metastatic melanoma,and several Chk2 inhibitors,including AZD7762,PF447736 and XL844,have already entered phase Ⅰ and Ⅱ clinical trials.However,clinical trials fail to confirm the anti-tumor efficacy of Chk2 inhibitors.
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