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OBJECTIVE: High altitude (HA) presents inhospitable environmental conditions that adversely affect human physiology and metabolism.Changes in pathophysiological functions are reported during high altitude exposure, and hypoxia can cause myocardial hypertrophy.However, few study have explored the effect of different altitude hypoxia (2260 m, 3300-3500 m) on hemin oxygenase (HO)-1/CO-bilirubin system in elderly patients (≥65 years old) with congestive heart failure.The aim of the present study was to evaluate the relationship between ventricular remodeling and changes of hemin oxygenase (HO)-1/CO-bilirubin system.