【摘 要】
：
Epithelial tissues are organized by two types of polarity: apico-basal (ABP) and planar cell (PCP) polarities.PCP was initially described in Drosophila wher
【机 构】
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Institut Paoli-Calmettes France
【出 处】
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2011第四届世界癌症大会暨乳腺癌峰会
论文部分内容阅读
Epithelial tissues are organized by two types of polarity: apico-basal (ABP) and planar cell (PCP) polarities.PCP was initially described in Drosophila where it controls the uniform orientation of hairs and bristles on the body.More generally, PCP mechanisms organize the polarization of many epithelial tissues and organs within the plane, and drive cell migration and cell intercalation of non-epithelial cells such as mesenchymal cells.While a large body of work has already shed light on the role of ABP genes (E-cadherin, lkbl, scribble,..) in cancer, much less is known about the role of PCP genes in tumor growth and dissemination.
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