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Objective Group cognitive behavior therapy (GCBT) was an effective treatment in improving self-management behaviors and quality of life for asthmatic patients.However,the effects of GCBT o n the underlying neurobiology remain unknown.Therefore,we explored the changes of brain spo ntaneous activity before and after GCBT in asthma.Methods 39 asthmatic patients and 60 health controls received resting-state functional magnetic resonance imaging (rs-fMRI) scan and clinical assessments at baseline.In addition,17 asthmatic patients completed GCBT treatment consisted of 8 sessions,and received the second fMRI scan and clinical evaluation at the 8-week period.