【摘 要】
:
The major factors involved in the age-related neurode generative disease, such as progressive decline in cognitive func tions and the loss of synaptic contacts, remain poorly under stood.There is sign
【机 构】
:
Institute of Experimental Neurogiology, Wenzhou Medical College, Wenzhou 325000, China
【出 处】
:
第十五届中国神经精神药理学学术会议
论文部分内容阅读
The major factors involved in the age-related neurode generative disease, such as progressive decline in cognitive func tions and the loss of synaptic contacts, remain poorly under stood.There is significant evidence indicating that chronic stress and neuronal vulnerability are interrelated events contributing to age-related pathologies.An acute uncontrollable stress can im pair high-frequency stimulation-induced long-term potentiation (LTP) in the CA1 region of hippocampus, which requires the stabilization of learning-induced synaptic changes.In contrast,chronic restraint stress induces structural alterations in hipp ocampal neurons, such as a progressive decrease in the volume of hippoeampus and dendritic hypertrophy, which are correlated to behavioral deficits in hippocampal-dependent working and ref erence memory.Indeed, in response to sustained stress, the brain undergoes a complex array of cellular and molecular chan ges that lead to maladaptive remodeling and learning and memory impairment.
其他文献
The nucleus accumbens (NAc) plays an important role in reward, pleasure, laughter, addiction, aggression, fear,and the placebo effect, however, its role in sleep-wake regulation remains unclear.Dopami
目的 自闭症发病率逐年上升,其与认知功能异常的神经环路失调关联性收到国内外研究者关注.然而,迄今仍未能阐明其确切病因和发病机制.我们以突触蛋白钙离子/钙调素依赖性蛋白激酶Ⅱ(Calcium/calmodulin-dependent protein kinaseⅡ,CaMKⅡ)相关信号为切入点展开研究.方法 SD大鼠孕12.5 d时随机分为自闭症组和对照组,VPA水溶液(240 g·L-1)造模.检
GABA transporter subtype 1 (GAT1) constructs high affinity reuptake sites for GABA in the CNS and regulates GA BAergic transmission.Compounds that inhibit GAT1 are targets for epilepsy treatment.Sedat
OBJECTIVE Fructus Akebiae (FAE) is a tradi tional Chinese herbal that has been used for the treatment of de pressive disorders in China.To determine the content of heder agenin and identify the substa
OBJECTIVCE Schizophrenia is a chronic, debili tating psychotic mental disorder.Many studies suggest that dopa mine D3 receptor (DAD3R) plays an important role in etioloy of schizophrenia, and selectiv
Clinical studies have demonstrated the effectiveness of an herbal preparation called Peony-Glycyrrhiza Decoction (PGD) in alleviating antipsychotic-induced hyperprolactinemia (hyperPRL).In the present
Whether benzodiazepines (BZD) have beneficial effects on the progress of chronic stress-induced impairment of hippocampal structural plasticity and major depression is uncer tain.The present study des
Insomnia is a common disorder seen in nearly 30%-35% of the general population worldwide, with a range of 10%-15% being assessed as moderate to severe disorders.Symptoms of insomnia include poor sleep
目的 观察性激素对雌性大鼠复吸和共患精神症状的影响.方法 成年雌性SD大鼠去卵巢后采用FR1训练程序建立海洛因静脉自身给药行为,连续训练14 d后消退,进行复吸测试,其后应用强迫游泳,高台十字迷宫等分别测试动物的抑郁和焦虑样症状.结果 正常对照组和去卵巢组大鼠的自身给药行为如有效反应数和海洛因注射针数没有明显差异,线索诱导和海洛因诱导的复吸行为两组之间也没有显著性差异.在强迫游泳实验中海洛因自身给
目的 Neuregulin1(NRG1)在神经发育中起着重要的作用。遗传学研究表明NRG1及其受体ErbB4是精神分裂症相关的易感基因。我们的研究目的是易感基因NRG1在神经发育过程中的表达变化与精神分裂症发病机制的相关性。方法 本研究旨在利用精神分裂症的神经病理模型及子宫内胚胎电转实验模型,结合RNA干扰技术(RNAi)、分子生物学及行为学检测等手段,以精神分裂症主要涉及的脑区:前额叶皮层区(P