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Bioorthogonal chemistries can be used to visualize and identify diverse classes of biomolecules in complex environments.Despite the tremendous success of these reactions in revealing new facets of cell and organismal biology,significant limitations remain:1 many of the most common reactions are incompatible with one another,limiting their utility for studies of multiple biomolecules in tandem,and 2 many bioorthogonal reagents are too large for tagging native biomolecules in live cells.