CAP/AECOPD Burden of Disease Community-acquired pneumonia (CAP)1,2,3-A leading cause of death in US and worldwide In US 5-6 million cases/yearApprox.1 million admissions/year (40％ one year mortality)1A single case of CAP requiring hospitalization is associated with an estimated 9 to 10 days of lost productivity1AECOPD (Acute Exacerbation of COPD)4-COPD ranks first among the burdens of diseases in China and accounts for one million deaths and five million disabilities each year (from WHO;Science Daily, Oct 2007)-Exacerbation leads to progressive lung function decline.