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Radiation-induced intestinal injury is a common complication in radiotherapy for solid organ malignancies in abdomen or pelvis.Currently there are no approved medical countermeasures for radiation-induced intestinal injury.Therefore,it is urgent to develop new treatments for radiation-induced intestinal injury.In the present study,we demonstrated that MSCs overexpression of a transgene for human manganese superoxide dismutase (MnSOD) could ameliorate radiation-induced intestinal syndrome.NOD/SCID mice received abdominal irradiation at a selected dose of 5 Gy,and then transfused intravenously with MnSOD-MSCs and monitored for 30-day body weight and survival.Colonization and differentiation of MnSOD-MSCs in the irradiated intestine were analyzed by histological and immunohistochemaical methods.