【摘 要】
：
Recent studies indicate that ketamine, a noncompetitive NMDA receptor antagonist, can produce rapid antidepressant effects within hours that sustains for we
【机 构】
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CAS Key Laboratory of Brain Function and Disease, School of Life Science, University of Science and
【出 处】
：
中国神经科学学会第九届全国学术会议暨第五届会员代表大会
论文部分内容阅读
Recent studies indicate that ketamine, a noncompetitive NMDA receptor antagonist, can produce rapid antidepressant effects within hours that sustains for weeks in patients resistant to conventional antidepressants that increase central serotonergic (5-HT) neurotransmission.We ask whether and how ketamine modulates synaptic plasticity in the schaffer-CA1 pathway of the hippocampus in rodents that is known to be involved in the pathology of major depressive disorder (MDD).Using in vivo field potential recordings, we found that metaplasticity at schaffer-CA1 pathway of the hippocampus is disrupted in forced swimming model of depression.However, after ketamine injection, metaplasticity in the same group of animals is restored to the level comparable to naive animals, apparently through mTOR-dependent synaptic formation.Therefore, the rapid antidepressant action ofketamine may be mediated by restoring metaplasticity at schaffer-CA 1 pathway of the hippocampus in rodents.
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