Cytoplasmic CD147 Contributes to Melanoma Invasion and Metastasis by Regulating Calcium/NFAT Pathway

来源 :2014第七届世界癌症大会 | 被引量 : 0次 | 上传用户：dyflovedyf

【摘要】

：

【作者】

：

Weiqi Zeng Juan Su Yiming Zhuo Xiang Chen

【机构】

：

Department of Dermatology Xiangya Hospital Central South University China

【出处】

：

2014第七届世界癌症大会

【发表日期】

：

2014年12期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　CD147 protein is encoded by BSG (basigin) gene, also is known as EMMPRIN.CD147 is a membrane protein, primarily localizes on cytoplasmic membrane, and elevated in multiple kinds of cancer tissues, including melanoma, hepatocarcinoma, breast cancer as well as lung cancer.We found CD 147 highly expressed in cytoplasm of melanoma tissue and cell lines.

其他文献

A Complex Effect of the Ephb6 Receptor on Breast Cancer Aggressiveness

Cancer aggressiveness is determined by multiple aspects of tumour biology controlled by receptor tyrosine kinases and cancer metastasis is often associated with a reduced expression of the EphB6 recep

会议

Isolation of Colorectal Cancer Stem-like Cells: Phenotypic Characterization and Tumorigenic Potentia

Colorectal cancer (CRC) is the third most prevalent form of cancer and leads to approximately 600,000 deaths annually.Recently, converging evidence has suggested that human cancer can be considered as

会议

Novel Insights into Regulation of Apoptosis in Uveal Melanoma: PERP-p53 Pathway

Down-regulation of PERP (p53 apoptosis effector related to PMP-22) correlates with the aggressive (monosomy 3) type of uveal melanoma (UM), the most common primary intraocular tumour in adults.Signall

会议

Investigation of the Signalling Pathways Controlling DAPK-1 Protein Degradation

Death Associated Protein Kinase 1 (DAPK) is a serine/threonine kinase involved in the regulation of multiple cellular events such as apoptosis, autophagy and proliferation.In cancer, DAPK has been ide

会议

Novel GPCR-mediated Oncogenic Signaling Pathways in Cancer Growth and Metastasis

Ovarian cancer patients show increased levels of lysophosphatidic acid (LPA) in their serum and ascetic fluid.Using DNA-protein interaction array, our studies have identified novel pathways through wh

会议

Effects of Long Noncoding RNAs on Androgen Receptor and Prostate Cancer

Prostate cancer is one of the biggest threats to mens health in the western world and it accounts for the second largest number of male cancer deaths in the United States.Although hormone therapy bene

会议

Role of H1 Linker Histones in Cancer

H1 linker histones are major chromatin structural proteins that associate with nucleosome core particles and play a key role in the folding of chromatin into higher order structures.Mammals contain mu

会议

Contribution of the Inhibition of STAT3 Signaling in Atractylenolide Ⅱ-afforded Anti-melanoma Effect

Advanced melanoma accounts for the vast majority of skin cancer deaths.It has been recently reported that STAT3 () is constitutively-activated in melanoma and contributes to tumor cell proliferation,

会议

L1ORF1p via Interacting with Ago2 Participates a DsRNA-mediated Regulation for Promoter Activity of

Background: LINE-1 (Long Interspersed Nucleotide Elements, L 1), an autonomous retrotransposon, is transiently activated in early stage of embryonic development and continuously activity in tumor test

会议

L1-5'UTRAgo2L1ORF1pantisense PromoterdsRNA

Mifepristone Suppresses Triple-negative Breast Cancer Cell Growth and Cancer Stem Cell Maintenance v

Triple-negative breast cancer (TNBC) is one of the most malignant breast cancers without effective therapeutic approaches currently.We previously reported that KLF5 is over-expressed in TNBC, KLF5 dep

会议

Cytoplasmic CD147 Contributes to Melanoma Invasion and Metastasis by Regulating Calcium/NFAT Pathway

与本文相关的学术论文