【摘 要】
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Background: In human placenta,syncytiotrophoblasts(STB) acts as an important component with secreting hormones such as hCG and PGF to maternal circulation for supporting a normal pregnancy.Defect of s
【机 构】
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Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University,Guangzhou 510
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Background: In human placenta,syncytiotrophoblasts(STB) acts as an important component with secreting hormones such as hCG and PGF to maternal circulation for supporting a normal pregnancy.Defect of syncytiotrophoblast differentiation may lead to pregnancy loss or birth defects.Although the regulation of syncytiotrophoblasts had been explained by some factors(growth factors,cAMP and negative feedback from the hormones),however,few reports elucidated the specific gene during this process.Recently,CRISP/Case 9 technique,which precisely manipulate endogenous gene expression,had opened a new chapter in understanding the gene function and regulation.RNF2,an E3 ubiquitin-protein ligase,usually acts as a member of Polycomb group (PcG) family and has been reported to be related to tumor invasion or metastasis.And in our previous study of STB,expression of RNF2 had been shown in differentiated BeWo trophoblast cells.
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