The Catalytic Triad are Essential for TSP50 to Perform Its Function in Cell Proliferation

来源 :中国细胞生物学学会全体会员代表大会暨第十二次学术大会 | 被引量 : 0次 | 上传用户：boshi9529

【摘要】

：

　　Testes-specific protease 50 (TSP50), a new threonine enzyme, shares similar aa sequence and enzymatic structure with many serine proteases and is proposed t

【作者】

：

Yu-YinLi[1]Yan-XinHuang[2]YingSun[3]Li-HuaZheng[3]Guan-NanWang[3]Yu-XinLi[4]Yong-LiBao[2]Zhen-BoSong[2]Lu-GuoSun[5]PingWu[2]YuZhang[4]CongFan[4]YinWu[4]Chun-LeiYu[1]

【机构】

：

National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal Universit

【出处】

：

中国细胞生物学学会全体会员代表大会暨第十二次学术大会

【发表日期】

：

2011年期

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　　Testes-specific protease 50 (TSP50), a new threonine enzyme, shares similar aa sequence and enzymatic structure with many serine proteases and is proposed to be a potential oncogene.TSP50 is up-regulated in breast cancer epithelial cells, and ectopic expression of TSP50 in TSP50-deficient Chinese hamster ovary (CHO) cells markedly promoted cell proliferation.However, the mechanism(s) by which TSP50 exerts its growth promotion effects are not yet fully understood.

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The Catalytic Triad are Essential for TSP50 to Perform Its Function in Cell Proliferation

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