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  5. Discovery of Novel Antibacterial Agents by Structure-based Drug Design, Synthesis and Biological Eva

Discovery of Novel Antibacterial Agents by Structure-based Drug Design, Synthesis and Biological Eva

来源 :第九届国际分子模拟与信息技术应用学术会议(ICMS&I2018) | 被引量 : 0次 | 上传用户：Ryanshel
【摘 要】
：
　　The emergence and spread of antibiotic resistance represent a severe global issue.New drug targets and novel lead compounds that exempt from cross-resistanc
【作 者】
：
Wenjie Xue Jie Xia Xiang Simon Wang Song Wu 
【机 构】
：
StateKeyLaboratoryofBioactiveSubstanceandFunctionofNaturalMedicines,InstituteofMateriaMedica,Chinese
【出 处】
：
第九届国际分子模拟与信息技术应用学术会议(ICMS&I2018)
【发表日期】
：
2018年5期
【关键词】
：
antibacterial drug LspA structure-based drug design lead optimization MRSA 
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　　The emergence and spread of antibiotic resistance represent a severe global issue.New drug targets and novel lead compounds that exempt from cross-resistance to existing drugs are urgently needed.LspA,a key enzyme involved in posttranslational processing of bacterial lipoprotein,looms as one of the new targets for antibacterial drugdiscovery.
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