Objective To investigate the efficacy and safety of single-or double-drug cytotoxic regimens as second-line treatment of advanced gastric cancer,and to figure the potential predictive factors associated with the outcome of different regimens.Methods Data from patients with advanced gastric cancer who have received second-line chemotherapy in the First Hospital of China Medical University from June 2010 to June 2018 were retrospectively collected.All patients clinic-pathological parameters and survival information were recorded.Patients were grouped in to double-or single-drug regimen group,and the efficacy and safety were analyzed.Survival analysis was performed using Kaplan-Meier curves and log-rank tests.